Mechanistic Target of Rapamycin Complex 1

An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.

Also Known As:

TOR Complex 1; TORC1; Target of Rapamycin Complex 1; mTORC1; mTORC1 Complex; Complex, mTORC1

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Mechanistic Target of Rapamycin Complex 1: 3687
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        TOR Serine-Threonine Kinases: 5978
        Mechanistic Target of Rapamycin Complex 1: 3687
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - TOR Serine-Threonine Kinases: 5978
        Mechanistic Target of Rapamycin Complex 1: 3687

Greg Sibbel Selected Research

Greg Sibbel Research Topics

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